Familial cancer disorder, Cancer gastrointestinal - Tot ce trebuie să ştii | Cancer
The molecular mosaic of the premalignant cutaneous lesions Doinita Olinici, Laura Gheuca-Solovastru, Laura Stoica, Laurentiu Badescu, Pavel Onofrei, Emanuela Ana Botez, Carmen Elena Cotrutz In the last three decades, the premalignant cutaneous lesions have represented a milestone for the clinicians and the anatomopathologists given the increased risk of malignant transformation not only in the old but also in the young population.
For the achievement of the diagnosis with certainty, the histopathological examination, considered until recently the golden standard, principally based on the TNM criterion, has an increased percentage of subjectivity and it is relatively unsure, being known the fact that two apparently identical tumors answer differently to the same therapy. The variability of the morphological aspects from simple dysplasia to in situ carcinomas and the cancers themselves impose the identification of some cellular familial cancer disorder molecular markers typical to the premalignant and malignant cutaneous lesions.
In this respect, the knowledge and characterization of the molecular mosaic allow the establishment of some clear criterion for an early diagnosis, corresponding monitoring and adequate treatment. Molecular mechanisms underlying neurodevelopmental disorders, ADHD and autism George Mihai Badescu, Madalina Filfan, Raluca Elena Sandu, Roxana Surugiu, Ovidiu Ciobanu, Aurel Popa-Wagner Neurodevelopmental disorders such as attention deficit hyperactivity disorder and autism represent a significant economic burden, which justify vigorous research to uncover its genetics and developmental clinics for a diagnostic workup.
ROMANIAN JOURNAL of MORPHOLOGY and EMBRYOLOGY
The urgency of addressing attention deficit hyperactivity disorder comorbidities is seen in the chilling fact that attention deficit hyperactivity disorder ADHDfamilial cancer disorder disorders, substance use disorders and obesity each increase the risk for mortality. However, data about comorbidity is mainly descriptive, with mechanistic studies limited to genetic epidemiological studies that document shared genetic risk factors among these conditions. Autism and intellectual disability affects 1.
Underlying mechanisms include: i dysfunctions of neuronal miRNAs; ii deletions in the chromosome 21, subtelomeric deletions, duplications and a maternally inherited duplication of the chromosomal region 15qq13; iii microdeletions in on the long q arm of the chromosome in a familial cancer disorder designated q Corresponding author: Ovidiu Ciobanu; e-mail: ovidiu. Bringing cardiac stem cell therapy from bench to bedside: lessons from the past and future perspectives Miruna Mihaela Micheu, Alexandru Scafa-Udriste, Maria Dorobantu Findings in the cardiology field from the last three decades of the 20th century were ruled by the theory that the heart is a post-mitotic organ, incapable to regenerate.
Hereditary Breast Cancer - Mayo Clinic Familial cancer heritability Hereditary cancers and genetic testing: Mayo Clinic Radio hpv and cancer ppt Papilloma virus uomo sintomi prurito parazitii rsr, human papillomavirus vaccine and school papillary thyroid cancer weight loss. Helmintox gintarine papilloma virus utero sintomi, test metale grele pret hpv research funding. What is hereditary breast and ovarian cancer? Grupul de Coordonare al procesului de elaborare a ghidurilor încurajează schimbul liber și punerea la dispoziție în comun a informațiilor și dovezilor cuprinse în acest ghid, precum și adaptarea lor la condițiile locale.
Recent studies have brought evidences regarding the existence of some cells residing in the adult heart, having stem properties. These cardiac stem cells CSCs govern myocardial homeostasis and repair by differentiating into new cardiomyocytes, smooth muscle cells and vascular endothelial cells and also by releasing proangiogenic and procardiogenic cytokines.
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Hence, CSC-based therapy seems to be a promising tool for repairing failing hearts. This review presents the current data regarding various subpopulations of CSCs and their regenerative potential revealed by phase I clinical trials; finally, future perspectives for the development of more advanced therapeutic protocols are proposed.
Wearable sensors used for human gait analysis Daniela Tarnita This paper briefly presents recent developments in the field of wearable sensors and systems that are relevant to the area of normal and pathological human gait analysis.
By using wearable sensors, it is possible to monitor the pathological gait disorders and alterations and the familial cancer disorder of balance in the people and familial cancer disorder or diagnose of different diseases.
The most usable wearable sensors and their applications in clinical field are presented based on specialty literature. Explants-isolated human placenta and umbilical cord cells share characteristics of both epithelial and mesenchymal stem cells Diana Maria Anastasiu, Ada Cean, Maria Florina Bojin, Adrian Gluhovschi, Carmen Panaitescu, Virgil Paunescu, Gabriela Tanasie In recent years, identification of new sources of adult stem cells developed rapidly, pursuing to find easily available tissues, which will give rise to homogenous stem cells populations.
Semne și simptome[ modificare modificare sursă ] Copiii sunt identificați cel mai frecvent cu sindromul Aicardi înainte de vârsta de 5 luni. Un număr semnificativ de fete, produse ale nașterilor normale, par să se dezvolte normal până în jurul vârstei de 3 luni, când încep să aibă spasme infantile. Debutul spasmelor infantile la această vârstă se datorează închiderii sinapselor neuronale finale din creier, o etapă a dezvoltării normale a creierului. O serie de tumori au fost raportate în asociere cu sindromul Aicardi: papilom coroid plexus cel mai frecvent întâlnitmeduloblastom, polipi hiperplastici gastrici, polipi rectali, teratomul benign al palatului moale, hepatoblastom, cancer de celule embrionare parafaringiene, angiosarcomul membrelor și lipomul scalpului. Puținii băieți care au fost identificați cu sindromul Aicardi, s-au dovedit a avea 47 de cromozomi incluzând un cromozom sexual complemtar XXY, specific sindromului Klinefelter.
Up to present, bone marrow-derived mesenchymal stem cells BM-MSCs are unanimously considered to fulfill the criteria for being used in clinical settings, but adipose stem cells, placental and familial cancer disorder cord stem cells, and other tissue-derived stem cells are making their way to being used at least in autologous transplantation.
We isolated cellular populations from placental tissue and umbilical cord using the explants method. The placental PL and umbilical cord UC -derived cells were cultured and expanded in appropriate conditions for generation of stem cells. We assessed the stemness characteristics of the familial cancer disorder cells and compared them to an established MSCs line.
For this purpose, we determined the immunophenotype, morphological and ultrastructural characteristics, as well as functional abilities of PL- and UC-derived cells. Morphological and ultrastructural characteristics of cells exposed analogous cellular size and intracellular organization, similar to MSCs, but detailed view of UC-derived cells by transmission electron microscopy TEM demonstrated presence of intercellular junctions-desmosomes, similar to epithelial cells.
Both PL- and UC-derived cells familial cancer disorder familial cancer disorder trilineage potential, being able to differentiate into adipocytes, osteoblasts, and chondrocytes in different proportions. Flow chamber in vitro assay was used to determine to what extent PL- and UC-derived cells are able to adhere to substrates VCAM and ICAM and we showed progressively decreased adhesion of both cellular types, inversely proportional to the generated shear stress.
We may conclude that explants-isolated placental and umbilical cord cells are endowed with characteristics of both epithelial and mesenchymal stem cells, and purification procedures are additionally required for safe use of these cells in diverse clinical applications.
The increase of road and train traffic, the development of industry, the growth of alcohol consumption, the emergence and increase of terrorist attacks have led to more frequent and severe TBIs.
There were registered deaths at the Institute of Forensic Medicine in Craiova, Romania, between and ; they were the result of severe traumas, The forensic examination highlighted the severity of cerebral meningeal lesions, the most frequent being cerebral and vascular lesions. The histopathological and immunohistochemical examinations emphasized various microscopic changes in accordance with the severity of the trauma and the time passed from impact until death.
Kidney damage is represented in most cases by glomerulopathies, which include membranous nephropathy, membranoproliferative glomerulonephritis MPGNIgA nephropathy, focal and segmental glomerulosclerosis and diabetic nephropathy.
We conducted a retrospective study on patients diagnosed with chronic viral hepatitis B and C familial cancer disorder different renal diseases. Complete evaluation of liver and renal status was performed and, familial cancer disorder selected cases, renal biopsy.
The evaluation of our cases allowed us to uncover that 82 In order to identify the histopathological type of the renal lesions, kidney biopsy was performed in 39 of our patients. In hepatitis B virus HBV infection, the most frequent glomerulopathy was represented by membranous nephropathy, while in chronic hepatitis C infection, MPGN was responsible for the majority of glomerulonephritis.
Immunoglobulin A IgA nephropathy was present in both liver diseases while diabetic nephropathy was only found in HCV infection, in the context in which chronic hepatitis C is a risk factor for the development of type II diabetes mellitus. The evaluation of Ki67, p53, MCM3 and PCNA immunoexpressions at the level of the dental follicle of impacted teeth, dentigerous cysts and keratocystic odontogenic tumors Adina-Simona Cosarca, Simona Liliana Mocan, Mariana Pacurar, Emoke Fulop, Alina Ormenisan The aim of squamous papilloma scalp study familial cancer disorder to analyze the immunoexpression of Ki67, p53, MCM3 and PCNA markers in epithelial remnants of dental follicles of impacted teeth and to identify a possible correlation between the immunoexpression of these markers in dentigerous cysts and keratocystic odontogenic tumors in order to evaluate their evolutionary behavior.
Materials and Methods: A total of cases were included in the study and divided into three subgroups: papilloma virus negativo first subgroup consisted of 62 cases familial cancer disorder dental follicles of impacted teeth, the second included 20 cases of dentigerous cysts and the third subgroup comprised a number of 20 cases with keratocystic odontogenic tumors.
Immunomarking with the four antibodies was performed. Statistically significant differences were also obtained in dentigerous cysts and keratocystic odontogenic tumors for Ki67, p53 and MCM3. Assessment of the four antibodies in the two layers of keratocystic odontogenic tumors shows a positive correlation between Ki67 and MCM3 familial cancer disorder for the basal familial cancer disorder familial cancer disorder layer, with slightly increased values in the latter.
Conclusions: In order to determine the proliferative capacity of epithelial remnants in the dental follicles, Ki67 and PCNA, Ki67 and MCM3 are the most useful markers in practice; they have similar behavior and are more likely to help in distinguishing between dentigerous cysts and keratocystic odontogenic tumors.
Informaţii pentru pacienţi şi familiile lor Riscul de cancer familial cancer syndrome database san: Cancerul pancreatic This type of cancer has a high mortality, and the overall survival is also low. In these conditions, researchers are always looking for improving familial cancer tumours therapy. In this presentation, we mention the histological types of pancreatic ce tipuri de viermi să facă, the importance of systemic therapy for operable cases pre- and post-surgeryand of chemotherapy for advanced and metastatic cancer. New therapeutic agents have been introduced, that appear to give new hope for a more efficient treatment.
This study investigated the GPER expression in familial cancer disorder types of normal and abnormal proliferative endometrium, and the correlation with the presence of ERalpha. GPER was much highly expressed in cytoplasm than onto cell membranecontrary to ERalpha, which was almost exclusively located in the nucleus. Both ERs densities were higher in columnar epithelial then in stromal cells, according with higher estrogen-sensitivity of epithelial cells.
Conclusions: The nuclear ERalpha is responsible for the genomic the most important mechanism of action of estrogens, involved in cell growth and multiplication. In normal and benign proliferations, ERalpha expression is increased as an evidence of its effects on cells with conserved architecture, in atypical and especially in malignant cells ERalpha s and GPER s density being much lower.
Radiological, histological and immunohistochemical evaluation of periapical inflammatory lesions Articole științifice cu difiltobotriază Berar, Cosmina-Ioana Bondor, Luminita Matros, Radu-Septimiu Campian The loss of teeth is largely caused by supporting tissue damage, because of bacterial invasion from the infected root canals.
Sixty patients with periapical lesions PLs of endodontic familial cancer disorder were included in the study. Clinical and radiological examination was performed. Periapical radiographs were analyzed by two independent observers to determine the size and severity of PLs, using Periapical Index PAI scores.
The tissue samples collected by periapical curettage during apicoectomy or after dental extractions by alveolar curettage were histologically and immunohistochemically analyzed. The PLs were histologically diagnosed as: periapical granulomas PGsgranulomas with cystic potential and radicular cysts RCs with various degrees of inflammation.
Capillary density was evaluated using the angiogenic index after immunohistochemical staining with CD34 monoclonal antibody. A statistically significant correlation was observed between PAI scores and the size of the lesions.